Strain-Specific Properties of E. coli Strain Nissle 1917

The E. coli strain Nissle 1917 (EcN) contained in ­­Mutaflor disposes of a number of properties which are important to its survival, colonization ability, and persistence in the intestinal ecosystem, and to its therapeutic efficacy. 9; 10; 11

  • Mobility due to type H1-flagella
  • Ability to colonize due to specific interaction of its ­flagellae with the mucin layer
  • Ability to form biofilms due to F1A-, F1C- and Curli-fimbriae
  • Antagonistic activity directed against foreign microbes due to antimicrobial microcins
  • Vitality and resilience (“biological fitness”) due to ­multiple iron uptake systems
  • Immunomodulatory effects due to strain-specific ­surface structures (special LPS = lipopolysaccharide) and synthesis of immunomodulatory signal substances
  • Anti-inflammatory effects
  • Stabilizing effect on the barrier function of the intestinal mucosa

9) Blum G et al. Properties of Escherichia coli strains of serotype O 6. Infection 1995; 23: 234–236.

10) Sonnenborn U, Schulze J. The non-pathogenic Escherichia coli strain Nissle 1917 – features of a versatile probiotic. Microbial Ecol Health Dis 2009; 21: 122–158.

11) Schiemann M et al. 125 Jahre E. coli – Bedeutung in Forschung und Medizin. Alfred-Nissle­-Gesellschaft (Hrsg.) Hagen, ISBN 3-9811198-4-3, 2010.

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